Established in 1980, the Prairie Region of the Canadian Music Centre includes the three prairie provinces: Alberta, Saskatchewan and Manitoba. Under the direction of John Reid, the offices are located on the University of Calgary campus in the state-of-the-art Taylor Family Digital Library. It is home to the Violet Archer Library which contains over 20,000 scores available for free circulation.

The Prairie Regional Office actively participates in the Western Canadian Music Awards, collaborating on the presentation of the Classical Nominees Showcase. As well, the office works closely with local music organizations to promote Canadian composers and Canadian music.